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Novapep

Australia|Biotechnology

Overview

Novapep, an Australian/US biotech, has developed a patented peptide structure called biparetideTM as an oral inflammatory bowel disease (IBD) therapy, which will be a cost effective, first-in-class drug. Biparetide has been shown in animals to be as effective as expensive, injectable biologic drugs (the gold standard) and superior to corticosteroids, but with minimal expected side effects. 

Novapep’s co-founders, Prof John Griffin and Prof Laurent Mosnier at the Scripps Research Institute in San Diego and Prof Chris Jackson at the University of Sydney have conducted over 15 years of ground breaking R&D in Activated Protein C (APC), which is anti-inflammatory, protects against unprogrammed cell death and has been shown to be effective in treating numerous diseases including inflammatory skin disorders and IBD. However, APC is very expensive to manufacture, needs to be stored at -70 C and is only being developed for high dose, intravenous administration in stroke and amyotrophic lateral sclerosis.

In response to APC's shortcomings, Novapep’s scientists invented a peptide structure called biparetide, which is a mimetic of APC, is more than an order of magnitude cheaper to manufacture and is stable at room temperature. The composition of matter patent for this invention was filed in 2019, which provides IP protection to 2039, with likely follow on patents, and it was licensed by Novapep from the Scripps in August, 2021. Novapep has previously raised ~$1,000,000 to optimise the molecule and conduct a number of animal studies demonatrating the efficacy of biparetide.

Novapep started a $1,000,000 equity capital raise in February and $350,000 has been raised to date. This funding will allow Novapep to progress its IBD program towards a Phase 1 clincial trial targetted to start at the end of 2025. Discussions are also underway with big pharma with the aim of concluding a partnering deal.

Problem and Solution

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Market Opportunity

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Competitive Advantages

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Highlights & Milestones

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Novapep

Novapep, an Australian/US biotech, has developed a patented peptide structure called biparediteTM as an oral inflammatory bowel disease therapy, which will be a cost effective first-in-class drug. Biparetide has been shown in animals to be as effective as expensive, injectable biologic drugs (a...

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